1 The subsequent adverse reactions transpired in at the least 5% of Depakote-treated patients and at an equal or bigger incidence for placebo than for Depakote: flu syndrome and pharyngitis.

In clients about two yrs of age who will be clinically suspected of having a hereditary mitochondrial condition, Depakote must only be employed just after other anticonvulsants have unsuccessful. This more mature group of individuals really should be carefully monitored through treatment method with Depakote for the event of acute liver harm with standard clinical assessments and serum liver screening. POLG mutation screening ought to be performed in accordance with present clinical follow [see WARNINGS AND PRECAUTIONS].

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Estrogen-Containing Hormonal Contraceptives Estrogen-containing hormonal contraceptives could raise the clearance of valproate, which may cause lowered concentration of valproate and perhaps enhanced seizure frequency.

If this SPL has inactivated NDCs mentioned through the FDA initiated compliance motion, they will be specified as such.

bleeding complications. Connect with your Health care provider if you have any signs and symptoms of bleeding, such as: bruising or red or purple spots on the skin

Other non-medication treatment you might be obtaining, which include speak therapy or compound abuse treatment. Your provider can describe how these unique treatment plans perform Along with the medication.

Depakote is additionally indicated for use as sole and adjunctive therapy from the remedy of simple and sophisticated absence seizures, and adjunctively in people with a number of seizure types that come with absence seizures.

Table two summarizes These adverse reactions noted for people in these trials the place the incidence rate from the Depakote-handled team was increased than five% and better than the placebo incidence, or the place the incidence in the Depakote-taken care of group was statistically appreciably higher when compared to the placebo team.

Impairment of Fertility In chronic toxicity experiments in juvenile and Grownup rats and canines, administration of valproate resulted in testicular atrophy and lessened spermatogenesis at oral doses of four hundred mg/kg/day or bigger in rats (roughly equivalent to or better than the maximum encouraged human dose (MRHD) on the mg/m2 foundation) and 150 mg/kg/day or bigger in puppies (approximately equivalent to or greater compared to the MRHD on a mg/m2 foundation).

G.I. Irritation People who working experience G.I. discomfort could reap the benefits of administration of your drug with foodstuff or by little by little increase the dose from an Preliminary small stage.

lower human body temperature (hypothermia). A drop in One's body temperature to under ninety five°F can materialize for the duration of therapy with DEPAKOTE. Connect with your healthcare company When you have any of the subsequent signs and symptoms:

are male and decide to father a baby. DEPAKOTE may perhaps lead to fertility difficulties, which can have an impact on your capability to father a kid. Discuss with your healthcare company if This really is a dilemma to suit your needs.

Depakote tablets are meant for oral administration. Depakote tablets really get more info should be swallowed entire and should not be crushed or chewed. Patients should be educated to acquire Depakote on a daily basis as prescribed.